GENERATION OF NOVEL IN VITRO FLEXIBLE KIDNEY ORGANOID MODEL TO INVESTIGATE THE ROLE OF EXTRACELLULAR VESICLES IN INDUCTION OF NEPHROGENESIS

Generation of novel in vitro flexible kidney organoid model to investigate the role of extracellular vesicles in induction of nephrogenesis

Abstract Background During kidney organogenesis, metanephric mesenchyme (MM) and ureteric bud (UB) interact reciprocally to form nephrons.Signaling stimuli involved in these interactions include Wnts, growth factors and nano/micro particles.How UB and MM are interacting is not completely understood.Our study investigated the signaling and communica

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Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells

Abstract Background It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death Kudzu Root (apoptosis).At first glance, the ability to transform and the ability to engender apoptosis seem to be contradictory.Interestingly, both abilities have been widely reported in the literature for t

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The formulation of sound transmission problems through the boundaries of three-dimensional media and through plates

Introduction.Modern physical models for calculating the propagation of plane longitudinal waves through media boundaries, based on the conditions of continuity of sound pressure and vibrational velocity, are implemented only with normal wave incidence.In all directions of wave propagation other than normal, the continuity conditions are not observe

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